References

9781107690943We are pleased to announce the publication of ‘The Design and Statistical Analysis of Animal Experiments’. This is the first textbook to describe not only the theory behind the statistical tests contained within InVivoStat but also how to perform statistical analyses using InVivoStat. See www.cambridge.org/9781107030787 for more details.

  • Bate ST and Clark RA (2014) The Design and Statistical Analysis of Animal Experiments. Cambridge University Press.

The following paper describes a comparison of the results generated by InVivoStat with those of other commonly used packages. If you plan to use InVivoStat in a paper, poster or other publication, then we recommend citing this paper:

  • Clark RA, Shoaib M, Hewitt KN, Stanford SC, Bate ST (2012) A comparison of InVivoStat with other statistical software packages for analysis of data generated from animal experiments. J Psychopharmacology 26(8) 1136-1142, DOI: 10.1177/0269881111420313.

The following papers have been prepared using InVivoStat. If you do publish your own work and have used InVivoStat then please let us know. We would like to add your paper to the list given on the website!

  • Abad S, Fole A, Olmo N, Pubill D, Pallàs M, Junyent F, Camarasa J, Camins A, Escubedo E (2014) MDMA enhances hippocampal-dependent learning and memory under restrictive conditions, and modifies hippocampal spine density. Psychopharmacology 231(5), 863-874.
  • Abad S, Junyent F, Auladell C, Pubill D, Pallàs M, Camarasa J, Escubedo E, Camins A (2014) 3, 4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility. Progress in Neuro-Psychopharmacology and Biological Psychiatry 54, 231-242.
  • Abdul Aziz NHK, Kendall DA, Pardon MC (2012) Prenatal exposure to chronic mild stress increases corticosterone levels in the amniotic fluid and induces cognitive deficits in female offspring, improved by treatment with the antidepressant drug amitriptyline . Behavioural Brain Research 231(1), 29–39.
  • Ali HM, Maksimenko A, Urbinati G, Chapuis H, Raouane M, Desmaële D, Yasuhiro H, Harashima H, Couvreur P, Massaad-Massade L (2014) Effects of Silencing the RET/PTC1 Oncogene in Papillary Thyroid Carcinoma by siRNA-Squalene Nanoparticles With and Without Fusogenic Companion GALA-Cholesterol. Thyroid 24(2), 327-338.
  • Ali HM, Urbinati G, Chapuis H, DesmaEle D, Bertrand J-R, Couvreur P, Massaad-Massade L (2014) Effects of siRNA on RET/PTC3 Junction Oncogene in Papillary Thyroid Carcinoma: From Molecular and Cellular Studies to Preclinical Investigations. PLoS ONE 9(4), e95964. doi:10.1371/journal.pone.0095964.
  • Allais-Bonnet A, Castille J, Pannetier M, Passet B, Elzaïat M, André M, Montazer-Torbati F, Moazami-Goudarzi K, Vilotte J-L, Pailhoux E (2016) A specific role for PRND in goat foetal Leydig cells is suggested by prion family gene expression during gonad development in goats and mice . FEBS Open Bio 6: 4–15. doi:10.1002/2211-5463.12002.
  • Almatroudi A, Husbands SM, Bailey CP, Bailey SJ (2015) Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice. Journal of Psychopharmacology 29(7), 812-821.
  • Andreasen JT, Bach A, Gynther M, Nasser A, Mogensen J, Strømgaard K, Pickering DS (2013) UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: Comparison with the NMDA receptor antagonist MK-801. Neuropharmacology 67, 193-200.
  • Andreasen JT, Fitzpatrick CM, Larsen M, Skovgaard L, Nielsen SD, Clausen RP, Troelsen K, Pickering DS (2015) Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action. Brain Research 1601, 117-126.
  • Andreasen JT, Redrobe JP, Nielsen EØ, Christensen JK, Olsen GM, Peters D (2013) A combined α7 nicotinic acetylcholine receptor agonist and monoamine reuptake inhibitor, NS9775, represents a novel profile with potential benefits in emotional and cognitive disturbances. Neuropharmacology 73, 183-191.
  • Baeken C, De Raedt R, Bossuyt A (2011) P. 2. b. 024 The influence of treatment-resistance on the serotonin 2A receptor in unipolar melancholic depression. European Neuropsychopharmacology 21, S381-S382.
  • Bailey S (2015) A Single Compound Alternative to a Buprenorphine/Naltrexone Combination, a functional kappa opioid receptor antagonist, produces antidepressant-like effects in mice. Journal of Psychopharmacology 29(8), A22.
  • Barnes SA, Young JW, Bate ST, Neill JC (2016) Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding. Behavioural brain research 300 (2016): 45-55.
  • Bate S, Karp NA (2014) A Common Control Group-Optimising the Experiment Design to Maximise Sensitivity. PloS one 9(12), e114872.
  • Bayramgurler D, Karson A, Yazir Y, Komsuoglu Celikyurt I, Utkan T (2012) P. 1. c. 014 Etanercept effect on aortic nitric oxide dependent vasorelaxation in an unpredictable chronic mild stress model of depression in rats. European Neuropsychopharmacology 22, S174-S175.
  • Bellance C, Khan JA, Meduri G, Guiochon-Mantel A, Lombès M, Loosfelt H (2013) Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexes. Molecular Biology of the Cell 24(9), 1363-1374.
  • Bianchi M, Bate S, Bauerle R, Baulieu EE, Fuchs E (2011) P. 2. b. 026 Psychosocial stress affects core body temperature in tree shrews: a new statistical model. European Neuropsychopharmacology 21, S382-S383.
  • Bianchi M, Baulieu EE (2012) 3ß-Methoxy-pregnenolone (MAP4343) as an innovative therapeutic approach for depressive disorders. PNAS 109(5), 1713-1718.
  • Blein S, Ollier R, Skegro D (2013) Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof. U.S. Patent 20,150,183,885, issued July 2, 2015.
  • Blein S, Ollier R, Skegro D, Walmsley A, Mottl H. (2015) ANTI-TRKA ANTIBODIES WITH ENHANCED INHIBITORY PROPERTIES AND DERIVATIVES THEREOF. U.S. Patent 20,150,183,885, issued July 2, 2015.
  • Carboni L, Lattanzio F, Candeletti S, Porcellini E, Raschi E, Licastro F, Romualdi P (2015) Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer’s disease patients. Neuroscience Letters 605, 44-48.
  • Casal-Dominguez JJ, Furkert D, Ostovar M, Teintang L, Clarke MJ, Traynor JR, Husbands SM, Bailey SJ (2014) Characterization of BU09059: a novel potent selective κ-receptor antagonist. ACS chemical neuroscience 5(3), 177-184.
  • Clark RA, Shoaib M, Hewitt KN, Stanford SC, Bate ST (2012) A comparison of InVivoStat with other statistical software packages for analysis of data generated from animal experiments. J Psychopharmacology 26(8), 1136-1142, DOI: 10.1177/0269881111420313.
  • Couch Y, Xie Q, Lundberg L, Sharp T, Anthony DC (2015) A Model of Post-Infection Fatigue Is Associated with Increased TNF and 5-HT 2A Receptor Expression in Mice. PloS one 10(7), e0130643.
  • Danielsen PL, Jorgensen NL, Jorgensen B, Karlsmark T, Agren MS (2013) Erythema persists longer than one year in split-thickness skin graft donor sites. Acta Dermato-Venereologica 93(3), 281-285.
  • de la Pisa GI, Cebrián C, Ortega JE, Meana JJ, Sulzer D (2014) Cytokine pathway disruption in a mouse model of schizophrenia induced by Munc18-1a overexpression in the brain. Journal of neuroinflammation 11(1), 128.
  • Dirian L, Galant S, Coolen M, Chen W, Bedu S, Houart C, Bally-Cuif L, Foucher I (2014) Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells. Developmental cell 30(2), 123-136.
  • Dudley JA, Weir RK, Yan TC, Grabowska EM, Grimmé AJ, Amini S, Stephens DN, Hunt SP, Stanford SC (2013) Antagonism of L-type Ca(v) channels with nifedipine differentially affects performance of wildtype and NK1R-/- mice in the 5-Choice Serial Reaction-Time Task. Neuropharmacology 64(1), 329-36, doi: 10.1016/j.neuropharm.2012.06.056. Epub 2012 Aug 1.
  • Ebada ME, Latif LM, Kendall DA, Pardon C (2014) Corticosterone protects against memory impairments and reduced hippocampal BDNF levels induced by a chronic low dose of ethanol in C57BL/6J mice. Rom J Morphol Embryol 55(4), 1303-1316.
  • El Bitar F, Meunier J, Villard V, Almeras M, Krishan K, Covey DF, Maurice T, Akwa Y (2014) Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aß25–35 peptide-induced toxicity in vitro and in vivo in mice. Psychopharmacology 231, 3293-3312.
  • Elzaiat M, Jouneau L, Thépot D, Klopp C, Allais-Bonnet A, Cabau C, Andre M, Chaffaux S, Cribiu EP, Pailhoux E, Pannetier M (2014) High-Throughput Sequencing Analyses of XX Genital Ridges Lacking FOXL2 Reveal DMRT1 Up-Regulation Before SOX9 Expression During the Sex-Reversal Process in Goats . Biology of Reproduction 91(6), 153 .
  • Embrechts S, Lavreysen H, Ver Donck L, Pemberton DJ (2012) P. 1. c. 015 Differential effects of acute and sub-chronic PCP in rodent cognition: reversal with a selective mGlu2 negative allosteric modulator RO4491533. European Neuropsychopharmacology 22, S175.
  • Fernández GAI, Rodríguez IER, Camarillo EES, Araujo MAG (2013) Valoración dosis-respuesta del efecto diurético de un extracto acuoso de pericarpio de Cucumis melo var. reticulatus Ser. Revista Cubana de Plantas Medicinales 18(3), 405-411.
  • Forbes S, Stafford S, Coope G, Heffron H, Real K, Newman R, Davenport R, Barnes M, Grosse J, Cox H (2015) Selective FFA2 agonism appears to act via intestinal PYY to reduce transit and food intake, but does not improve glucose tolerance in mouse models. Diabetes 64(11), 3763-3771.
  • Gaskin PLR (2014) Evaluation of novel dual-hit models of ‘schizophrenia-like’ symptoms in the rat. Doctoral dissertation University of Nottingham.
  • Gaskin PLR, Alexander SPH, Fone KCF (2014) Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of ‘schizophrenia-like’ behaviour in the rat. Psychopharmacology 231, 2533-2545.
  • Isea Fernández GA, Rodríguez Rodríguez IE, Sánchez Camarillo EE, Gil Araujo MA (2013) Valoración dosis-respuesta del efecto diurético de un extracto acuoso de pericarpio de Cucumis melo var. reticulatus Ser . Revista Cubana de Plantas Medicinales 18(3), 405-411.
  • Kalinichev M, Le Poul E, Boléa C, Girard F, Campo B, Fonsi M, Royer-Urios I, Browne SE, Uslaner JM, Davis MJ, Raber J, Duvoisin R, Bate ST, Reynolds IJ, Poli S, Celanire S (2014) Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders. Journal of Pharmacology and Experimental Therapeutics 350(3),495-505.
  • Karp NA, Segonds-Pichon A, Gerdin AB, Ramírez-Solis R, White JK (2012) The fallacy of ratio correction to address confounding factors. Laboratory Animals 46(3), 245-252.
  • Kurbatova N, Mason JC, Morgan H, Meehan TF, Karp NA (2015) PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data. PloS one 10(7), e0131274.
  • Ladurelle N, Gabriel C, Viggiano A, Mocaer E, Baulieu EE and Bianchi M (2012) Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology 221(3), 493-509, DOI: 10.1007/s00213-011-2597-5.
  • Dirian L (2014) Origine embryonnaire des cellules souches neurales adultes du pallium de poisson z_ebre. Doctoral dissertation Universit_e Paris Sud.
  • Lattanzio F, Carboni L, Carretta D, Rimondini R, Candeletti S, Romualdi P (2014) Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice. Neuroscience 256, 360-369, DOI: 10.1016/j.neuroscience.2013.10.017.
  • Lau SR, Christensen ST, Andreasen JT (2013) Patients’ preferences for patient-centered communication: A survey from an outpatient department in rural Sierra Leone. Patient Education and Counseling 93(2), 312-318.
  • Lerch S, Brandwein C, Dormann C, Gass P, Chourbaji S (2014) What makes a good mother? Implication of inter-, and intrastrain strain “cross fostering” for emotional changes in mouse offspring. Behavioural Brain Research 274, 270-281.
  • Lerch S, Brandwein C, Dormann C, Gass P, Chourbaji S (2015) Bred to breed?! Implications of continuous mating on the emotional status of mouse offspring. Behavioural brain research 279, 155-165.
  • Lerch S, Brandwein C, Dormann C, Gass P, Chourbaji S (2015) Mice Age-does the age of the mother predict offspring behaviour?. Physiology & Behavior 147, 157-162.
  • Lewis, DI (2011) In vivo Work, in Effective Learning in the Life Sciences: How Students can Achieve their Full Potential (ed D. J. Adams). John Wiley & Sons, Ltd, Chichester, UK DOI: 10.1002/9781119976646.ch5.
  • Lynch JJ, Castagné V, Moser PC, Mittelstadt SW (2011) Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies. Journal of Pharmacological and Toxicological Methods 64(1), 74-80.
  • Martínez-Clemente J, López-Arnau R, Abad S, Pubill D, Escubedo E, Camarasa J (2014) Dose and Time-Dependent Selective Neurotoxicity Induced by Mephedrone in Mice. PloS ONE 9(6), e99002.
  • Meunier CNJ, Amar M, Lanfumey L, Hamon M, Fossier P (2013) 5-HT1A receptors direct the orientation of plasticity in layer 5 pyramidal neurons of the mouse prefrontal cortex. Neuropharmacology 71, 37-45.
  • Meunier CNJ, Callebert J, Cancela JM, Fossier P (2015) Effect of Dopaminergic D1 Receptors on Plasticity Is Dependent of Serotoninergic 5-HT1A Receptors in L5-Pyramidal Neurons of the Prefrontal Cortex. PloS ONE 10(3), e0120286.
  • Moreno JL, Seto J, Hanks JB, González-Maeso J (2015) Techniques for the Study of GPCR Heteromerization in Living Cells and Animal Models. In Serotonin Receptor Technologies. Springer New York 95, 21-36.
  • Muguruza C, Lehtonen M, Aaltonen N, Morentin B, Meana JJ, Callado L (2013) Quantification of endocannabinoids in postmortem brain of schizophrenic subjects. Schizophrenia research 148(1),145-150.
  • Muguruza C, Moreno JL, Umali A, Callado LF, Meana JJ, González-Maeso J (2013) Dysregulated 5-HT2A receptor binding in postmortem frontal cortex of schizophrenic subjects. European Neuropsychopharmacology 23(8), 852-864.
  • Narayanan R, Kishan PV, Kavitha CM, Seethalakshmi S, Parvathavarthini S, Bhuvaneswari K (2012) Rimonabant improves spatial-novelty object recognition memory and valsartan is proamnesic in a dual maze dual scopolamine mouse model. Presented at CBP 2012 (Annual International Conference on Cognitive & Behavioral Psychology, February 2012, Singapore). Digital Library as CBP 2012 Proceedings 2251-1865 (Print), 2251-1881 (E-Periodical).
  • Novellas J, López-Arnau R, Pubill D, Camarasa J, Escubedo E (2015) Concentrations of MDPV in rat striatum correlate with the psychostimulant effect. Journal of Psychopharmacology 29(11), 1209-1218 .
  • Oh DH, Kim SH (2011) P. 2. b. 025 Neuropathological abnormalities of astrocytes, GABAergic neurons and pyramidal neurons in the dorsolateral PFC of patients with major depressive disorder. European Neuropsychopharmacology 21, S382.
  • Papazoglou IK, Jean A, Gertler A, Taouis M, Vacher CM (2014) Hippocampal GSK3β as a Molecular Link Between Obesity and Depression. Molecular Neurobiology 52(1), 363-374.
  • Parker, RMA, Browne WJ (2014) The Place of Experimental Design and Statistics in the 3Rs. ILAR Journal 55(3), 477-485.
  • Pavot P, Carbognin E, Martin JR (2015) PKA and cAMP/CNG channels independently regulate the cholinergic Ca2+-response of Drosophila mushroom body neurons. ENEURO 2.2, ENEURO-0054.
  • Pérez-Cáceres D, Ciudad-Roberts A, Rodrigo MT, Pubill D, Camins A, Camarasa J, Escubedo E, Pallas M (2013) Depression-like behavior is dependent on age in male SAMP8 mice. Biogerontology 14(2), 165-176.
  • Pillidge K, Porter AJ, Dudley JA, Tsai YC, Heal DJ, Stanford SC (2014) The behavioural response of NK1R‐/‐mice to guanfacine resembles its clinical profile in treatment of ADHD. British journal of pharmacology 171(20), 4785-4796 .
  • Pillidge K, Porter AJ, Vasili T, Heal DJ, Stanford SC (2014) Atomoxetine reduces hyperactive/impulsive behaviors in neurokinin-1 receptor ‘knockout’mice. Pharmacology Biochemistry and Behavior 127, 56-61.
  • Pillidge KM (2015) Predictive validity of the neurokinin-1 knockout mouse in research into Attention Deficit Hyperactivity Disorder. Doctoral dissertation UCL (University College London).
  • Porter AJ (2015) The Role of the Neurokinin-1 Receptor in Behaviour and Cognition: an interaction with the Brain Renin Angiotensin System and its implications for Attention Deficit Hyperactivity Disorder. Doctoral dissertation UCL (University College London).
  • Porter AJ, Pillidge K, Grabowska EM, Stanford SC (2015) The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene ‘knockout’ mice: Sex differences and implications for the treatment of attention-deficit hyperactivity disorder. European Neuropsychopharmacology 25(4), 512-521.
  • Porter AJ, Pillidge K, Stanford SC, Young JW (2016) Differences in the performance of NK1R / (‘knockout’) and wildtype mice in the 5 choice continuous performance test. Behavioural Brain Research 298, 268-277.
  • Porter AJ, Pillidge K, Tsai YC, Dudley JA, Hunt SP, Peirson SN, Brown LA, Stanford SC (2015) A lack of functional NK1 receptors explains most, but not all, abnormal behaviors of NK1R-/- mice. Genes, Brain and Behavior 14(2), 189-199.
  • Rivero G, Gabilondo AM, García-Sevilla JA, La Harpe R, Morentín B, Meana JJ (2015) Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment. Schizophrenia Research 161(2), 446-451.
  • Sadler A, Bailey S (2015) Chronic restraint stress increases depression-related behaviour in the sucrose preference test in juvenile and adult mice. Journal of Psychopharmacology 29(8), A17.
  • Sadler AM, Bailey SJ (2013) Validation of a refined technique for taking repeated blood samples from juvenile and adult mice. Laboratory Animals 47(4), 316-319.
  • Schofield D, Sleeman MA, Chessell IP, Hatcher J, Lowe D (2015) Compounds and methods for treating pain. U.S. Patent 20, 150, 274, 818, issued October 1, 2015.
  • Scullion GA, Hewitt KN, Pardon MC (2013) Corticotropin-Releasing Factor Receptor 1 Activation During Exposure to Novelty Stress Protects Against Alzheimer’s Disease-Like Cognitive Decline in AβPP/PS1 Mice. Journal of Alzheimer’s Disease 34(3), 781-793.
  • Smith PF (2012) A note on the advantages of using linear mixed model analysis with maximal likelihood estimation over repeated measures ANOVAs in psychopharmacology: comment on Clark et al. (2012).. Psychopharmacology 26(12), 1605-1607, DOI: 10.1177/0269881112463471.
  • Smith PF (2013) A comparison of univariate and multivariate statistical and data mining approaches to the behavioural and biochemical effects of vestibular loss related to the hippocampus. Doctoral dissertation Massey University.
  • Stroth N, Svenningsson P. (2015) S100B interacts with the serotonin 5-HT 7 receptor to regulate a depressive-like behavior. European Neuropsychopharmacology 25(12), 2372-2380.
  • Sun X, Yang H, Sturgill D, Oliver B, Rabinow L, Samson ML (2015) Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons. G3: Genes| Genomes| Genetics g3-115.
  • Weir RK, Dudley JA, Yan TC, Grabowska EM, Peña-Oliver Y, Ripley TL, Stephens DN, Stanford SC, Hunt SP (2013) The influence of test experience and NK1 receptor antagonists on the performance of NK1R-/-and wild type mice in the 5-Choice Serial Reaction-Time Task. Journal of Psychopharmacology 28(3), 270-281.
  • Yah-se KA, Nguyen HP, Ellenbroek B, Schreiber R (2013) Reversal learning and associative memory impairments in a BACHD rat model for Huntington disease. PLOS ONE 8(11), e68584.
  • Yah-se KA, Nguyen HP, Schreiber R, Ellenbroek B (2013) Assessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for Huntington disease. PLOS ONE 8(7), e68584.